5-Amino-1MQ Single vial · Cellular Senescence Research
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For laboratory research use only. Not for human or veterinary use.
Buying at volume? 5-Amino-1MQ factory direct
About 5-Amino-1MQ+
About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small synthetic molecule, not a peptide. It blocks nicotinamide N-methyltransferase (NNMT), an enzyme that adds a methyl group to nicotinamide, a form of vitamin B3. It came from a series of quinolinium compounds made by a research group at the University of Texas Medical Branch (Neelakantan et al., J Med Chem 2017). In cultured mouse fat cells, it and related compounds lowered the enzyme's product and raised NAD+ levels. In mice made obese on a high-fat diet, 11 days of treatment led to lower body weight and fat mass than in untreated mice, with no change in food intake (Neelakantan et al., Biochem Pharmacol 2018). Later mouse studies from the same group looked at diet changes, fatty liver and muscle in old mice. The evidence is limited: nearly all published studies come from one research group and a company founded by its lead scientist, and we found no independent replication. There are no published human studies, so its effects, safety and handling in the human body are unknown. Supplied for laboratory research use only.
Mechanism
5-Amino-1MQ blocks nicotinamide N-methyltransferase (NNMT), an enzyme that moves a methyl group from S-adenosylmethionine (SAM) onto nicotinamide; computer docking suggests it sits in the pocket where nicotinamide normally binds. In cultured mouse fat cells, blocking NNMT lowered the enzyme's product (1-methylnicotinamide), raised NAD+ and SAM, and lowered fat synthesis (Neelakantan et al., 2018). In the same study the compound did not block related methyltransferases or the NAD+ pathway enzymes tested, including SIRT1. Whether these changes explain the results seen in mice has not been shown directly.
Research on 5-Amino-1MQ
Storage and handling
- Sealed and lyophilised, store at 2 to 8°C away from light and moisture. Minus 20°C for longer.
- Once reconstituted, keep refrigerated and avoid repeated freeze and thaw cycles.
- Bacteriostatic water is the usual diluent. The volume added sets the concentration in mg per mL.
- Vials carry a batch number for your laboratory records. Recent independent lab results are published in our COA Library.
FAQs
Can I order a single vial of 5-Amino-1MQ without a minimum order?+
Yes. The single-vial range exists precisely so a laboratory can take one vial of 5-Amino-1MQ rather than a full Factory Direct kit of 10. There is no minimum order quantity on this format.
How quickly does a 5-Amino-1MQ single vial ship in the UK?+
Single vials are held in our UK facility and dispatched within 24 hours of a cleared payment on working days, on a tracked UK service. Orders placed at the weekend go out on the next working day.
How does the single vial differ from the factory-direct box?+
The compound and the manufacturing source are the same. The Factory Direct kit is a 10-vial pack and a lower per-vial cost, while the single vial is one vial from UK stock for small-scale or pilot work.
What purity is stated for 5-Amino-1MQ?+
99%+ manufacturer-stated purity. Buyers are encouraged to run independent third-party verification, and our testing directory lists laboratories that perform it.
Is this 5-Amino-1MQ vial for human use?+
No. Every Peptx product, including the single-vial range, is supplied strictly for laboratory research. It is not for human consumption, diagnosis, treatment or any clinical use.
What is 5-Amino-1MQ?+
5-Amino-1MQ is a small synthetic molecule, not a peptide, that blocks the enzyme nicotinamide N-methyltransferase (NNMT). It was made by a university research group studying NNMT in metabolism. It is supplied here for laboratory research use only.
How does 5-Amino-1MQ work?+
It blocks NNMT, an enzyme that adds a methyl group to nicotinamide, a form of vitamin B3. In cultured mouse fat cells this lowered the enzyme's product and raised levels of NAD+ and SAM, two molecules involved in energy metabolism and methylation.
Has 5-Amino-1MQ been tested in people?+
No. Published studies are in cultured cells and mice, nearly all from one research group, including a study in mice made obese on a high-fat diet (Neelakantan et al., 2018). There are no published human studies.
How is 5-Amino-1MQ stored?+
Store the freeze-dried powder sealed, cold and away from light, following standard laboratory storage procedures for research compounds. See the product specifications for detailed storage requirements.
Other single vials in Cellular Senescence Research
Strictly for laboratory research. Not for human consumption, diagnosis or treatment.