TB-500 is a synthetic peptide fragment based on the active region of Thymosin Beta-4 (Tβ4), a 43-amino-acid intracellular protein. It is referenced in the published tissue-repair, cell-migration and actin-regulation research literature. Supplied as a research reference material only.
TB-500 (Thymosin B4)
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Dispatch
48h factory
Form
Lyophilized
MOQ
10 vials
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Multi-source
What is TB-500 (Thymosin Beta-4)?
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4, one of the most abundant intracellular proteins in the human body. Thymosin Beta-4 was originally isolated from the thymus gland and plays a critical role in actin sequestration, cell migration, and tissue repair.
The active region of Thymosin Beta-4 — the 17-amino acid sequence Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and surrounding residues — is what gives TB-500 its biological activity. This fragment retains the key functional properties of the full-length protein while being more practical for research applications.
TB-500 has been extensively studied in veterinary research, particularly in equine medicine, and is increasingly used in preclinical tissue repair studies. Peptx offers research-grade TB-500 from vetted manufacturers (independent ISO 17025 lab testing and community feedback) with typically 99%+ purity (HPLC); guaranteed minimum varies by compound.
Mechanism of Action
TB-500 exerts its effects primarily through interaction with actin, the most abundant intracellular protein, and through promotion of cell migration and differentiation.
Actin Regulation
TB-500 sequesters G-actin (monomeric actin), preventing excessive polymerisation and promoting cytoskeletal remodelling. This actin-binding activity is central to its role in cell migration and wound healing.
Cell Migration
By promoting cytoskeletal reorganisation and lamellipodium formation, TB-500 enhances the directional migration of keratinocytes, endothelial cells, and other cell types critical to tissue repair.
Inflammatory pathway modulation (preclinical)
Published research has reported downregulation of inflammatory cytokines and chemokines at injury sites in animal repair models, characterising a microenvironment associated with tissue repair rather than chronic inflammation.
Research Applications
- Wound Healing: Studying dermal wound closure, re-epithelialisation, and granulation tissue formation in cutaneous injury models.
- Cardiac Research: Investigating cardioprotective effects and cardiac tissue repair following ischaemic injury in preclinical models.
- Corneal Repair: Examining corneal epithelial wound healing and the role of Thymosin Beta-4 in ocular surface repair.
- Musculoskeletal: Studying skeletal muscle regeneration, tendon repair, and the effects on satellite cell activation and differentiation.
- Neurological Research: Investigating the effects on oligodendrocyte differentiation and myelination in central nervous system repair models.
Storage, Handling, and Reconstitution
Long-Term Storage
Store unreconstituted lyophilized TB-500 at -20°C for optimal stability (24+ months). Protect from light and moisture.
Short-Term Storage
Unreconstituted vials may be stored at 2-8°C for up to 60 days during active research use.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. TB-500 is readily soluble. Add solvent gently along the vial wall and swirl to dissolve.
Post-Reconstitution
Store at 2-8°C and use within 21 days. Aliquot for extended storage to avoid repeated freeze-thaw cycles.
For laboratory handling and storage information, see our research equipment overview.
Quality Assurance
Peptx sources all TB-500 (Thymosin B4) exclusively from vetted manufacturers, gauged on independent testing at accredited ISO 17025 labs plus active community feedback, all maintaining rigorous internal quality control.
Multi-source vetted suppliers
Suppliers are vetted across multiple signals: independent ISO 17025 lab testing and live community feedback.
48 Hour Dispatch
Orders dispatched within 48 hours from the factory with full tracking.
Frequently Asked Questions About TB-500 (Thymosin B4)
What is TB-500 used for in research?▼
What is the difference between TB-500 and Thymosin Beta-4?▼
What purity is Peptx TB-500?▼
Can TB-500 be combined with BPC-157 in research?▼
Where can I buy TB-500 in the UK?▼
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TB-500 (Thymosin B4) is sold by Peptx strictly for laboratory and research purposes only. It is not intended for human consumption, veterinary use, food additive, or cosmetic applications. By purchasing this product, the buyer confirms it will be used exclusively for qualified scientific research.