KPV Single vial · Tissue Repair Research
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For laboratory research use only. Not for human or veterinary use.
Buying at volume? KPV factory direct
About KPV+
About KPV
KPV is a synthetic tripeptide (lysine-proline-valine). It matches the last three amino acids, positions 11 to 13, of alpha-melanocyte-stimulating hormone (alpha-MSH), a 13-amino-acid hormone cut from the precursor protein proopiomelanocortin. Researchers became interested in it because, in lab tests, it kept some of alpha-MSH's effects on inflammatory signalling without its effect on skin pigment (Brzoska et al., Endocr Rev 2008). Published work is in cells and mice. In human gut-lining cell lines, KPV was taken up by the peptide transporter PepT1 and lowered activation of NF-kappaB, a switch for inflammatory genes, and in two chemically induced mouse colitis models treated mice had lower inflammatory cytokine levels than untreated mice (Dalmasso et al., Gastroenterology 2008). A German group reported similar findings in DSS colitis and a T-cell transfer colitis model, including in mice without a working MC1 receptor. Much of the later work packages KPV in nanoparticles or gels for mouse and rat colitis studies. There are no published human trials of KPV, and its human pharmacokinetics, safety and whether the mouse findings apply to people are not known. Supplied for laboratory research use only.
Mechanism
How KPV acts is not fully settled. It is carried into gut-lining and immune cells by the peptide transporter PepT1 (Dalmasso et al., 2008), and in human airway cells it moved into the nucleus and blocked the import of p65 RelA, part of NF-kappaB, which switches on inflammatory genes. Unlike alpha-MSH, KPV appears to act largely without melanocortin receptors: it did not raise cAMP (the messenger these receptors normally switch on) in macrophages, and its effects persisted in mice lacking a working MC1 receptor (Getting et al., 2003). These findings come from cell and mouse studies.
Research on KPV
Storage and handling
- Sealed and lyophilised, store at 2 to 8°C away from light and moisture. Minus 20°C for longer.
- Once reconstituted, keep refrigerated and avoid repeated freeze and thaw cycles.
- Bacteriostatic water is the usual diluent. The volume added sets the concentration in mg per mL.
- Vials carry a batch number for your laboratory records. Recent independent lab results are published in our COA Library.
FAQs
Can I order a single vial of KPV without a minimum order?+
Yes. The single-vial range exists precisely so a laboratory can take one vial of KPV rather than a full Factory Direct kit of 10. There is no minimum order quantity on this format.
How quickly does a KPV single vial ship in the UK?+
Single vials are held in our UK facility and dispatched within 24 hours of a cleared payment on working days, on a tracked UK service. Orders placed at the weekend go out on the next working day.
How does the single vial differ from the factory-direct box?+
The compound and the manufacturing source are the same. The Factory Direct kit is a 10-vial pack and a lower per-vial cost, while the single vial is one vial from UK stock for small-scale or pilot work.
What purity is stated for KPV?+
99%+ manufacturer-stated purity. Buyers are encouraged to run independent third-party verification, and our testing directory lists laboratories that perform it.
Is this KPV vial for human use?+
No. Every Peptx product, including the single-vial range, is supplied strictly for laboratory research. It is not for human consumption, diagnosis, treatment or any clinical use.
What is KPV?+
KPV is a synthetic tripeptide (lysine-proline-valine) that matches the last three amino acids of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in cell and mouse models of inflammation, mainly of the gut. It is supplied here for laboratory research use only.
How does KPV work?+
KPV is carried into gut-lining and immune cells by the peptide transporter PepT1, and inside cells it lowered activation of NF-kappaB, a switch for inflammatory genes. Unlike alpha-MSH, it appears to act largely without melanocortin receptors. This evidence comes from cell and mouse studies.
Has KPV been tested in people?+
No. There are no published human trials of KPV. The evidence comes from cell studies and mouse colitis models, where treated mice had lower inflammation measures than untreated mice (Dalmasso et al., 2008).
How is KPV stored?+
Store the freeze-dried powder sealed, cold and away from light, following standard laboratory peptide storage procedures. See the product specifications for detailed storage requirements.
Other single vials in Tissue Repair Research
Strictly for laboratory research. Not for human consumption, diagnosis or treatment.