Ara-290 Single vial · Tissue Repair Research
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For laboratory research use only. Not for human or veterinary use.
Buying at volume? Ara-290 factory direct
About Ara-290+
About Ara-290
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide modelled on part of erythropoietin (EPO), the hormone that drives red blood cell production. It was designed by Michael Brines, Anthony Cerami and colleagues to act on the innate repair receptor, a pairing of the EPO receptor with CD131 (the beta common receptor), without stimulating red cell production itself (Brines et al., PNAS 2008). Most laboratory work is in rats and mice, in models of nerve injury, nerve pain, diabetes and ageing. Small placebo-controlled trials in people all had authors from the developing company. Three were in sarcoidosis with small nerve fibre loss (22, 38 and 64 patients) and one in type 2 diabetes with nerve pain (49 patients), each lasting four weeks. They tracked symptom scores and nerve fibre counts in the cornea, with mixed results: in the largest trial the main nerve measure differed from placebo at only one of three dose levels, and pain scores fell in every group, including placebo (Culver et al., 2017). A 12-week study of nine people with diabetic macular oedema found no change in vision or retinal thickness. No trial has been independently repeated, cibinetide is not an approved medicine, and long-term safety is unknown. Supplied for laboratory research use only.
Mechanism
ARA-290 binds the innate repair receptor, a complex of the EPO receptor and CD131 (the beta common receptor), rather than the paired EPO receptors that drive red cell production. This receptor complex is reported to appear mainly in injured or inflamed tissue. In rat and mouse studies, binding was linked to lower markers of inflammation, for example less activation of immune cells in the spinal cord after nerve injury in rats. The peptide did not raise red cell production in cell or animal tests.
Research on Ara-290
Storage and handling
- Sealed and lyophilised, store at 2 to 8°C away from light and moisture. Minus 20°C for longer.
- Once reconstituted, keep refrigerated and avoid repeated freeze and thaw cycles.
- Bacteriostatic water is the usual diluent. The volume added sets the concentration in mg per mL.
- Vials carry a batch number for your laboratory records. Recent independent lab results are published in our COA Library.
FAQs
Can I order a single vial of Ara-290 without a minimum order?+
Yes. The single-vial range exists precisely so a laboratory can take one vial of Ara-290 rather than a full Factory Direct kit of 10. There is no minimum order quantity on this format.
How quickly does a Ara-290 single vial ship in the UK?+
Single vials are held in our UK facility and dispatched within 24 hours of a cleared payment on working days, on a tracked UK service. Orders placed at the weekend go out on the next working day.
How does the single vial differ from the factory-direct box?+
The compound and the manufacturing source are the same. The Factory Direct kit is a 10-vial pack and a lower per-vial cost, while the single vial is one vial from UK stock for small-scale or pilot work.
What purity is stated for Ara-290?+
99%+ manufacturer-stated purity. Buyers are encouraged to run independent third-party verification, and our testing directory lists laboratories that perform it.
Is this Ara-290 vial for human use?+
No. Every Peptx product, including the single-vial range, is supplied strictly for laboratory research. It is not for human consumption, diagnosis, treatment or any clinical use.
What is ARA-290?+
ARA-290, also called cibinetide, is a synthetic 11-amino-acid peptide modelled on part of the hormone erythropoietin (EPO). It was designed to act on the innate repair receptor without stimulating red blood cell production. It is supplied here for laboratory research use only.
How does ARA-290 work?+
It binds the innate repair receptor, a complex of the EPO receptor and CD131 (the beta common receptor). In rat and mouse studies, binding was linked to lower markers of inflammation. Unlike EPO, it did not raise red cell production in animal tests.
Has ARA-290 been tested in people?+
Yes, in small trials lasting four to twelve weeks, most of them placebo-controlled, mainly in sarcoidosis with small nerve fibre loss (22 to 64 patients) and in type 2 diabetes with nerve pain (49 patients). Results were mixed: some nerve fibre and symptom measures differed from placebo, but in the largest trial pain scores fell in all groups, including placebo. All trials involved the developing company, and none has been independently repeated.
How is ARA-290 stored?+
Store the freeze-dried powder sealed, cold and away from light, following standard laboratory peptide storage procedures. See the product specifications for detailed storage requirements.
Other single vials in Tissue Repair Research
Strictly for laboratory research. Not for human consumption, diagnosis or treatment.