GH Secretagogue
    Investigational

    CJC-1295 With DAC

    Also known as: CJC-1295 no DAC, Modified GRF 1-29

    GHRH analogue. Stimulates steady GH release.

    Research overview

    CJC-1295, also known as CJC-1295 no DAC or Modified GRF 1-29, is a growth hormone research peptide extensively studied in laboratory settings for its effects on growth hormone regulation. This synthetic analogue represents a modified version of growth hormone-releasing hormone (GHRH) designed with enhanced stability characteristics. The compound operates through a well-defined mechanism whereby it binds to GHRH receptors located on pituitary somatotroph cells. This binding interaction stimulates the synthesis and secretion of growth hormone, making it a valuable tool for researchers investigating growth hormone pathways. A key advantage of CJC-1295 in research models is its extended half-life compared to natural GHRH, allowing for more sustained experimental observations. Research studies indicate that CJC-1295 demonstrates several primary effects in laboratory models, including stimulation of growth hormone release and subsequent increases in insulin-like growth factor-1 (IGF-1) levels. Additionally, research has examined its influence on body composition parameters and recovery processes in experimental settings. The compound has achieved a B-grade evidence classification, reflecting a substantial body of research supporting its mechanisms and effects. This classification indicates that CJC-1295 has been subject to rigorous scientific investigation, making it a reliable choice for researchers studying growth hormone pathways and related physiological processes. For laboratory applications, CJC-1295 offers researchers a stable and well-characterised tool for investigating growth hormone regulation, IGF-1 signalling cascades, and associated metabolic processes in controlled experimental environments.

    Mechanism of action

    Binds GHRH receptor on pituitary somatotrophs, stimulating GH synthesis and secretion. Extended half-life vs natural GHRH.

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