Tissue Repair Research
    Preclinical / Research

    PEG MGF

    Also known as: PEGylated MGF, PEG-Mechano Growth Factor

    PEGylated form of Mechano Growth Factor (MGF), a splice variant of IGF-1. Studied in satellite-cell research.

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    Research overview

    PEG-MGF is a PEGylated form of Mechano Growth Factor (MGF), the IGF-1Ec splice variant expressed in muscle tissue in response to mechanical load. Unmodified MGF is broken down within minutes in serum; attaching polyethylene glycol extends its stability, which is why the PEGylated form is used in longer laboratory studies. Published work centres on satellite-cell activation and IGF-1 pathway signalling in cell and animal models. Supplied for laboratory research use only.

    Mechanism of action

    PEG-MGF is the C-terminal peptide of Mechano Growth Factor (the IGF-1Ec splice variant) with a polyethylene glycol chain attached. PEGylation slows enzymatic breakdown, giving a longer half-life in research models than unmodified MGF.

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