PE 22-28 Single Vial
Cognitive / Nootropic · single vial · no minimum order
PE 22-28 is available as an individual vial shipped from our UK facility, so a laboratory can take one vial rather than a wholesale box. Every single vial is the same material as the factory-direct range, held in the UK for tracked next-working-day delivery, and supplied strictly for laboratory research.
No minimum order
One vial is a valid order
24 hour UK dispatch
Tracked, working days
99%+ stated purity
Buying at volume instead?
The wholesale format is a multi-vial factory-direct box with a lower per-vial cost and a minimum order quantity. See PE 22-28 factory direct.
PE 22-28
About PE 22-28
PE-22-28, also known as Spadin or TREK-1 blocker, is a cognitive classification research peptide that has garnered attention in neuroscience research for its unique mechanism of action. This compound operates by selectively blocking TREK-1 potassium channels, which play crucial roles in regulating neuronal excitability and mood-related pathways. The mechanism of PE-22-28 centres on its inhibition of TREK-1 potassium channels, leading to enhanced neurotransmitter release, particularly serotonin. This action contributes to the compound's observed rapid antidepressant effects in research models. Additionally, the modulation of synaptic plasticity through this pathway suggests potential cognitive-enhancing properties. Primary research effects observed in laboratory studies include rapid antidepressant effects, improved cognitive function, enhanced mood stabilisation, increased synaptic plasticity, and potential anxiolytic effects. These findings have positioned PE-22-28 as a compound of significant interest in neuropsychiatric research. The current evidence grade for PE-22-28 is classified as C, indicating that whilst promising effects have been observed, the research base requires expansion. Existing evidence derives primarily from animal studies, which demonstrate the compound's rapid antidepressant and cognitive-enhancing properties. However, no published human clinical trials are currently available, highlighting the need for further research to confirm efficacy and safety profiles in human models. Researchers investigating PE-22-28 should note that this peptide represents an emerging area of neuroscience research, with its TREK-1 channel blocking mechanism offering a novel approach to studying mood regulation and cognitive enhancement pathways.
Mechanism
PE-22-28 works by blocking the TREK-1 potassium channels, which are involved in regulating neuronal excitability and mood. By inhibiting these channels, PE-22-28 may enhance neurotransmitter release, particularly serotonin, leading to rapid antidepressant effects. This action can also improve cognitive function by modulating synaptic plasticity.
Reported research findings
- Rapid antidepressant effects
- Improved cognitive function
- Enhanced mood stabilization
- Increased synaptic plasticity
- Potential anxiolytic effects
Why a single vial
Pilot and method work
A single vial covers assay development, method validation or a short pilot run without committing to a wholesale quantity of PE 22-28.
UK held, fast turnaround
Vials ship from our UK facility on a tracked service, so a study is not waiting on an international consignment or a customs queue.
Same material as the box
Single vials are drawn from the same vetted manufacturing source as the factory-direct range, with the same batch documentation.
Predictable spend
Small laboratories and independent researchers can budget one vial at a time rather than a full minimum order quantity.
Storage and handling
Before reconstitution
Store the sealed lyophilised vial at 2 to 8°C, protected from light and moisture. Longer term storage at minus 20°C is common laboratory practice.
After reconstitution
Reconstituted solution is held refrigerated at 2 to 8°C and used within the window appropriate to the compound. Avoid repeated freeze and thaw cycles.
Reconstitution
Bacteriostatic water is the usual diluent. Our reconstitution calculator works out the diluent volume for a given target concentration.
Documentation
Every vial carries a batch number for traceable laboratory records, and independent verification is encouraged.
See the reconstitution guide and the calculator.
FAQs
Can I order a single vial of PE 22-28 without a minimum order?+
Yes. The single-vial range exists precisely so a laboratory can take one vial of PE 22-28 rather than a full wholesale box. There is no minimum order quantity on this format.
How quickly does a PE 22-28 single vial ship in the UK?+
Single vials are held in our UK facility and dispatched within 24 hours of a cleared payment on working days, on a tracked UK service. Orders placed at the weekend go out on the next working day.
How does the single vial differ from the factory-direct box?+
The compound and the manufacturing source are the same. The factory-direct box is a wholesale multi-vial pack with a minimum order quantity and a lower per-vial cost, while the single vial is one vial from UK stock for small-scale or pilot work.
What purity is stated for PE 22-28?+
99%+ manufacturer-stated purity. Buyers are encouraged to run independent third-party verification, and our testing directory lists laboratories that perform it.
Is this PE 22-28 vial for human use?+
No. Every PeptX product, including the single-vial range, is supplied strictly for laboratory research. It is not for human consumption, diagnosis, treatment or any clinical use.
What is PE-22-28?+
PE-22-28, also known as Spadin, is a cognitive classification research peptide that blocks TREK-1 potassium channels. It is used in laboratory studies investigating neuronal excitability, mood regulation, and cognitive function pathways.
How does PE-22-28 work?+
PE-22-28 works by blocking TREK-1 potassium channels, which are involved in regulating neuronal excitability and mood. This inhibition enhances neurotransmitter release, particularly serotonin, and modulates synaptic plasticity in research models.
What is the half-life of PE-22-28?+
The half-life data for PE-22-28 is not currently available in published research. Researchers should consult current literature and conduct appropriate pharmacokinetic studies for their specific research applications.
How is PE-22-28 stored?+
Specific storage requirements for PE-22-28 should follow standard peptide storage protocols. Researchers should store the compound in appropriate laboratory conditions and consult supplier guidelines for optimal storage parameters.
Other single vials in Cognitive / Nootropic
Strictly for laboratory research. Not for human consumption, diagnosis or treatment.