Mechanism
5-Amino-1MQ vs MOTS-c: Mechanism Comparison
Two small molecule research compounds targeting metabolic health through different mechanisms. 5-Amino-1MQ inhibits NNMT to preserve NAD precursors. MOTS-c is a mitochondrial peptide activating AMPK.
Side-by-side comparison
| Attribute | 5-Amino-1MQ | MOTS-c |
|---|---|---|
| Class | Small molecule NNMT inhibitor | Mitochondrial derived peptide |
| Mechanism | Preserves NAD precursors and SAM | AMPK activation, insulin sensitivity |
| Route | Oral | Subcutaneous injection |
| Strongest evidence | Rodent obesity and muscle ageing | Rodent insulin sensitivity, exercise mimetic |
Key differences
- ·5-Amino-1MQ inhibits the NNMT enzyme to preserve methyl donors and NAD
- ·MOTS-c is a 16 amino acid mitochondrial encoded peptide activating AMPK
- ·5-Amino-1MQ is small molecule, orally active
- ·MOTS-c requires subcutaneous injection
Research summary
Neelakantan et al. (2018) characterised 5-Amino-1MQ as a selective NNMT inhibitor with effects on adipose and muscle metabolism. Lee et al. (2015) defined MOTS-c metabolic action. Both target ageing metabolic decline through orthogonal mechanisms.